Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway.

Yasuhiro NishidaAllah NawazTomonobu KadoAkiko TakikawaYoshiko IgarashiYasuhiro OnogiTsutomu WadaToshiyasu SasaokaSeiji YamamotoMasakiyo SasaharaJohji ImuraKumpei TokuyamaIsao UsuiTakashi NakagawaShiho FujisakaYagi KunimasaKazuyuki Tobe

Published in: Journal of cachexia, sarcopenia and muscle (2020)

We concluded that AX treatment stimulated mitochondrial biogenesis and significantly ameliorated insulin resistance through activation of AMPK pathway in the skeletal muscle.

Keyphrases

skeletal muscle
insulin resistance
oxidative stress
type diabetes
high fat diet
polycystic ovary syndrome
glycemic control
adipose tissue
high fat diet induced
metabolic syndrome
combination therapy
weight loss
protein kinase
replacement therapy