Novel endotypes of antisynthetase syndrome identified independent of anti-aminoacyl transfer RNA synthetase antibody specificity that improve prognostic stratification.

Shiyu WuXinyue XiaoYingfang ZhangXinxin ZhangGuochun WangQing-Lin Peng

Published in: Annals of the rheumatic diseases (2024)

Anti-ARS antibodies were not significant in stratifying ASS patients into subgroups with greater homogeneity in RP-ILD and prognoses. Novel ASS endotypes were identified independent of anti-ARS specificity and differed in clinical outcomes and transcriptional signatures, providing new insights into the pathogenesis of ASS.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
case report
transcription factor
oxidative stress
nucleic acid
idiopathic pulmonary fibrosis
heat shock protein