Alpha-galactosylceramide pre-treatment attenuates clinical symptoms of LPS-induced acute neuroinflammation by converting pathogenic iNKT cells to anti-inflammatory iNKT10 cells in the brain.
Tae-Cheol KimHyun Jung ParkSung Won LeeYun Hoo ParkLuc Van KaerSeokmann HongPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2024)
Our findings provide strong evidence that α-GalCer-induced pre-activation of iNKT cells expands iNKT10 cells, mitigating depressive-like behaviors and brain infiltration of inflammatory immune cells induced by LPS-induced acute neuroinflammation. Thus, we suggest the prophylactic potential of iNKT cells and α-GalCer against acute neuroinflammation.
Keyphrases
- induced apoptosis
- cell cycle arrest
- anti inflammatory
- inflammatory response
- endoplasmic reticulum stress
- lipopolysaccharide induced
- multiple sclerosis
- cell death
- physical activity
- cerebral ischemia
- cognitive impairment
- brain injury
- subarachnoid hemorrhage
- liver failure
- bipolar disorder
- endothelial cells
- functional connectivity
- smoking cessation
- respiratory failure
- high glucose