Diminished AdipoR1/APPL1 Interaction Mediates Reduced Cardioprotective Actions of Adiponectin against Myocardial Ischemia/Reperfusion Injury in Type-2 Diabetic Mice.

Chao RenWei YiBo JiangErhe GaoJiali LiangBo ZhangZhe YangDezhi ZhengYong Zhang

Published in: Stem cells international (2023)

This study demonstrates for the first time that lipocalin can attenuate myocardial ischemia/reperfusion injury through the AdipoR1-APPL1 signaling pathway and that the reduction of AdipoR1/APPL1 interaction plays an important role in cardiac APN resistance to MI/R injury in diabetic mice.

Keyphrases

left ventricular
ischemia reperfusion injury
signaling pathway
metabolic syndrome
oxidative stress
pi k akt
insulin resistance
type diabetes
adipose tissue