Involvement of an IgE/Mast cell/B cell amplification loop in abdominal aortic aneurysm progression.
Alexia LosteMarc ClémentSandrine DelboscKevin GuedjJean SénémaudAnh-Thu GastonMarion MorvanGuillaume EvenGrégory GautierAlexander EggelMichel ArockEmanuele ProcopioCatherine DeschildreLiliane LouedecJean-Baptiste MichelLydia DeschampsYves CastierRaphaël CoscasJean-Marc AlsacPierre LaunayGiuseppina CaligiuriAntonino NicolettiMarie Le BorgnePublished in: PloS one (2023)
Our data suggest that MC located close to aortic wall fissures are activated by adventitial TLO B cell-produced IgEs and participate to their own activation by providing support for further IgE synthesis through IL-4 production. By preventing prompt repair of aortic subclinical fissures, such a runaway MC activation loop could precipitate aneurysmal progression, suggesting that MC-targeting treatments may represent an interesting adjunctive therapy for reducing AAA progression.