Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions.
Eileen S CarpenterAhmed M ElhossinyPadma KadiyalaJay LiJake McGueBrian GriffithYaqing ZhangJacob EdwardsSarah NelsonFatima LimaKatelyn L DonahueWenting DuAllison C BischoffDanyah AlomariHannah WatkoskeMichael MatteaStephanie TheCarlos EspinozaMeredith BarrettChristopher J SonnendayNicholas OldenNicole PetersonValerie GunchickVaibhav SahaiArvind RaoFilip BednarJiaqi ShiTimothy L FrankelMarina Pasca Di MaglianoPublished in: bioRxiv : the preprint server for biology (2023)
The causes underlying the onset of pancreatic cancer remain largely unknown, hampering early detection and prevention strategies. Here, we show that PanIN are abundant in healthy individuals and present at a much higher rate than the incidence of pancreatic cancer, setting the stage for efforts to elucidate the microenvironmental and cell intrinsic factors that restrain, or, conversely, promote, malignant progression.