Anti-EGFR Antibodies in the Management of Advanced Colorectal Cancer.
Pashtoon Murtaza KasiManuel Geroy AfableCameron HertingMariusz LukanowskiZhaohui JinPublished in: The oncologist (2023)
Colorectal cancer is the third most common cancer worldwide, and incidence is rising in younger individuals. Anti-EGFR antibodies, including cetuximab and panitumumab, have been incorporated into standard-of-care practice for patients with advanced disease. Herein, we review the molecular characteristics of these agents and the trials that lead to their approvals. Further, we discuss clinical implications of data regarding biomarkers that dictate treatment selection, different dosing strategies, and side effect management. Finally, we look towards the future and describe contexts in which these agents are currently being investigated clinically with a focus on combinations with MAPK-targeted therapies and immunotherapy. Overall, this review provides historical context, current clinical usage, and future directions for anti-EGFR antibodies in advanced colorectal cancer.
Keyphrases
- small cell lung cancer
- epidermal growth factor receptor
- tyrosine kinase
- healthcare
- current status
- primary care
- signaling pathway
- palliative care
- quality improvement
- oxidative stress
- metastatic colorectal cancer
- electronic health record
- radiation therapy
- squamous cell carcinoma
- high resolution
- deep learning
- single molecule
- combination therapy
- atomic force microscopy