Identification of genetically predicted DNA methylation markers associated with non-small cell lung cancer risk among 34,964 cases and 448,579 controls.
Xiaoyu ZhaoMeiqi YangJingyi FanMei WangYifan WangZhibin HuMeng ZhuYue JiangOlga Y GorlovaIvan P GorlovDemetrius AlbanesStephen LamAdonina TardónChu ChenGary E GoodmanStig E BojesenMaria Teresa LandiMattias JohanssonAngela RischH-Erich WichmannHeike BickeböllerDavid C ChristianiGad RennertSusanne M ArnoldPaul BrennanJohn K FieldSanjay S SheteLoïc Le MarchandGeoffrey LiuRayjean J HungAngeline S AndrewLambertus A KiemeneyShanbeh ZienolddinyKjell GrankvistMikael JohanssonNeil E CaporasoPenella J WollPhilip LazarusMatthew B SchabathMelinda C AldrichAlpa V PatelMichael P A DaviesHongXia MaGuangfu JinZhibin HuChristopher I AmosHongbing ShenJuncheng DaiPublished in: Cancer (2023)
The epigenetic consequences of DNA methylation in lung cancer development are still largely unknown. This study used summary data of large-scale genome-wide association studies to investigate the associations between genetically predicted levels of methylation biomarkers and non-small cell lung cancer risk at the first time. This study looked at how well larotrectinib worked in adult patients with sarcomas caused by TRK fusion proteins. These findings will provide a unique insight into the epigenetic susceptibility mechanisms of lung cancer.