Combining Blood Gene Expression and Cellfree DNA to Diagnose Subclinical Rejection in Kidney Transplant Recipients.

Sookhyeon ParkKexin GuoRaymond L HeilmanEmilio D PoggioDavid J TaberChristopher L MarshSunil M KurianSteve KleiboekerJuston WeemsJohn HolmanLihui ZhaoRohita SinhaSusan BrietigamChristabel RebelloMichael M AbecassisJohn J Friedewald

Published in: Clinical journal of the American Society of Nephrology : CJASN (2022)

A combination of blood-based biomarkers can improve detection and provide less invasive monitoring for subclinical rejection. In this study, the gene expression profile detected more cellular rejection, whereas donor-derived cfDNA detected more antibody-mediated rejection.

Keyphrases

gene expression
dna methylation
genome wide
copy number
single molecule
circulating tumor
cell free
transcription factor
loop mediated isothermal amplification