Inactivation of Cys674 in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase.
Gang LiuFuhua WuXiaoli JiangYumei QueZhexue QinPingping HuKin Sing Stephen LeeJian YangChunyu ZengBruce D HammockXiaoyong TongPublished in: British journal of pharmacology (2020)
The inactivation of SERCA2 C674 promotes the development of hypertension by inducing ER stress and sEH. Our study highlights the importance of C674 redox status in BP control and the contribution of SERCA2 to sodium homeostasis and BP in the kidney.