A pH-responsive cascade nanoplatform with circulating oxygen supply for collaborative breast cancer treatment.

Xiaonan GaoZhikai JiaYaoying ChengMingyi OuyangLin FengYuzhuo WangBo Tang Kehua Xu

Published in: Chemical communications (Cambridge, England) (2022)

A pH-responsive cascade nanoplatform based on ZIF-8 disintegrates in the weakly acidic tumor microenvironment to release MnO 2 , CaO 2 and Ce6. The drugs can cyclically generate O 2 for sonodynamic therapy, consume glutathione to tune the redox hemostasis, and produce cytotoxic ˙OH to kill tumor cells via chemical dynamics therapy.

Keyphrases

photodynamic therapy
cancer therapy
drug release
quality improvement
drug delivery
quantum dots
chemotherapy induced