Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions.

Kathrine Sivertsen ÅsrudRonja BjørnstadReidun KopperudLine PedersenBarbara van der HoevenTine V KarlsenCecilie Brekke RyghFitz-Roy CurryMarit BakkeRolf K Reed Olav Tenstad Stein Ove Døskeland

Published in: Acta physiologica (Oxford, England) (2020)

Our results conform to the hypothesis that Epac1-dependent mechanisms protect against diabetes insipidus by maintaining renal papillary osmolarity and the integrity of CD TJs.

Keyphrases

type diabetes
cardiovascular disease
glycemic control
blood brain barrier
single molecule
high fat diet induced
skeletal muscle
insulin resistance