Protein Phosphatase 2A-Dependent Mitotic hnRNPA1 Dephosphorylation and TERRA Formation Facilitate Telomere Capping.

Jiang-Dong SuiZheng TangBenjamin P C ChenPing HuangMeng-Qi YangNuo-Han WangHao-Nan YangHong-Lei TuQing-Ming JiangJing ZhangYing WangYong-Zhong Wu

Published in: Molecular cancer research : MCR (2022)

This study demonstrates that the PP2A-dependent hnRNPA1 dephosphorylation and TERRA accumulation facilitates the formation of the protective capping structure of newly replicated telomeres, thus exerting essential oncogenic role in tumorigenesis.

Keyphrases

cell cycle
binding protein