Exploring the Genetic Risk of Childhood Daytime Urinary Incontinence: A Genome-Wide Association Study.
Anders BreinbjergCecilie Siggaard JørgensenG Bragi WaltersJakob GroveThomas Damm AlsKonstantinos KamperisLilja StéfansdóttirJanne P ThirstrupBritt BorgClara AlbiñanaBjarni Johann VilhjalmssonViðar Ö EðvarðssonHreinn StefánssonPreben Bo MortensenEsben AgerboThomas M WergeAnders Dupont BørglumDitte DemontisKári StefánssonSøren RittigJane Hvarregaard ChristensenPublished in: The Journal of urology (2024)
Common genetic variants contribute to the risk of childhood DUI, and genes important in neuronal development and detrusor smooth muscle activity were implicated. These findings may help guide identification of new treatment targets.
Keyphrases
- smooth muscle
- urinary incontinence
- genome wide association study
- genome wide
- bioinformatics analysis
- early life
- obstructive sleep apnea
- childhood cancer
- copy number
- dna methylation
- depressive symptoms
- physical activity
- transcription factor
- brain injury
- botulinum toxin
- genome wide identification
- replacement therapy
- smoking cessation
- genome wide analysis