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P2X7 -Mediated Antigen-Independent Activation of CD8 + T Cells Promotes Salt-Sensitive Hypertension.

Lance N BensonKatherine S DeckChristoph J MoraYunping GuoTonya M RaffertyLin-Xi LiLu HuangJ Tucker AndrewsZhiqiang QinDaniel W TrottRobert S HooverYunmeng LiuShengyu Mu
Published in: Hypertension (Dallas, Tex. : 1979) (2024)
Our findings suggest a novel mechanism by which CD8Ts are activated in hypertension to exacerbate salt retention and infer that the P2X7 receptor on CD8Ts may represent a new therapeutic target to attenuate T-cell-mediated immunopathology in hypertension.
Keyphrases
  • blood pressure
  • nk cells