Inhibition of ACAA1 Restrains Proliferation and Potentiates the Response to CDK4/6 Inhibitors in Triple-Negative Breast Cancer.

Wen-Ting Peng Xi Jin Xiao-En Xu Yun-Song Yang Ding Ma Zhi-Ming Shao Yi-Zhou Jiang

Published in: Cancer research (2023)

ACAA1 is highly expressed in TNBC, serving as a potential therapeutic target in ACAA1-high tumors and a predictive biomarker of resistance to CDK4/6 inhibitors for RB1-proficient patients.

Keyphrases

end stage renal disease
cell cycle
ejection fraction
newly diagnosed
chronic kidney disease
signaling pathway
peritoneal dialysis
cell proliferation
prognostic factors
patient reported outcomes