Systemic response to rupture of intracranial aneurysms involves expression of specific gene isoforms.

Michal KorostynskiMarcin PiechotaRafal MorgaDzesika HoinkisSlawomir GoldaMagdalena ZygmuntTomasz DziedzicMarek MoskalaAgnieszka SlowikJoanna Pera

Published in: Journal of translational medicine (2019)

IA rupture in the acute phase strongly influences the transcription profiles of peripheral blood cells as well as the composition of mononuclear cells. A specific pattern of gene expression alteration was found, suggesting a depression of lymphocyte response and enhancement of monocyte activity.

Keyphrases

peripheral blood
induced apoptosis
gene expression
cell cycle arrest
endoplasmic reticulum stress
depressive symptoms
genome wide
endothelial cells
transcription factor
sleep quality
binding protein