Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress.

T W JungH KimS Y ParkW ChoH OhH J LeeA M Abd El-AtyA HacimuftuogluJi Hoon Jeong

Published in: Journal of endocrinological investigation (2022)

These results suggest that STA activates AMPK/HO-1 signaling, resulting in reduced inflammation and ER stress, thereby improving skeletal muscle insulin resistance. Using STA as a natural ingredient, this research successfully treated insulin resistance and type 2 diabetes.

Keyphrases

insulin resistance
skeletal muscle
endoplasmic reticulum stress
type diabetes
high fat diet
oxidative stress
induced apoptosis
polycystic ovary syndrome
high fat diet induced
glycemic control
metabolic syndrome
diabetic rats
adipose tissue
high glucose
pi k akt