Carbapenem-Resistant Pseudomonas aeruginosa Spondylodiscitis Treated with Ceftazidime-Avibactam: A Case Report with Literature Review.
Guilherme José da Nóbrega DandaAndreia Craveiro FrancoElisangela Ana Paula GomesVinícius Vianna Abreu MontanaroBernardo José Alves Ferreira MartinsVitor Viana Bonan de AguiarPublished in: Infection and drug resistance (2023)
Pyogenic spondylodiscitis (PS) is a highly morbid and potentially fatal bacterial infection with an increasing incidence in recent decades. Its diagnosis and treatment are challenging, especially with the expansion of multidrug- or extensively drug-resistant bacteria. We report a rare case of PS caused by carbapenem-resistant Pseudomonas aeruginosa (CRPA) that was treated with ceftazidime-avibactam (C/A). The choice of C/A therapy was based on the patient's bacterial sensitivity profile and intolerance to the initial therapeutic regimen (polymyxin B and meropenem). The total antimicrobial treatment time was seven weeks. The evolution of the clinical course met the cure criteria, which was characterized by remission of signs and symptoms, normalization of inflammatory markers, and radiological improvement over 18 months of clinical follow-up. This is a rare case of CRPA spondylodiscitis that responded to C/A treatment.
Keyphrases
- rare case
- drug resistant
- gram negative
- multidrug resistant
- pseudomonas aeruginosa
- acinetobacter baumannii
- cystic fibrosis
- klebsiella pneumoniae
- case report
- staphylococcus aureus
- bariatric surgery
- risk factors
- systemic lupus erythematosus
- rheumatoid arthritis
- newly diagnosed
- physical activity
- decision making
- cell therapy