Genetic variants associated with severe cutaneous adverse drug reactions induced by carbamazepine.

Nontaya NakkamParinya KonyoungWarayuwadee AmornpinyoNiwat SaksitSomsak TiamkaoUsanee KhunarkornsiriKanyarat KhaesoOranuch PattanacheewapullTeekayu Plangkoon JornsPansu ChumworathayiWichittra Tassaneeyakul

Published in: British journal of clinical pharmacology (2021)

The HLA-B*15:02 allele is the strongest genetic marker for the prediction of SJS/TEN induced by CBZ in Thai population. Screening for other alleles in the HLA-B75 serotype increases sensitivity for prediction of a life-threatening SCARs caused by CBZ.

Keyphrases

adverse drug
electronic health record
drug induced
dengue virus
emergency department
early onset
genome wide
klebsiella pneumoniae
copy number
zika virus
platelet rich plasma
escherichia coli