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Primary vulval melanoma and genital lichen sclerosus.

Evanthia MastorakiGeorgios KravvasKate DearSharmaine SimMariel JamesRichard WatchornAiman HaiderPeter ElleryAlex FreemanMahfooz BashaEmma EdmondsChristopher Barry Bunker
Published in: Skin health and disease (2024)
The presence of genital LS in as high as 64% of our vulval melanoma cases might indicate a causative relationship between genital LS and vulval melanoma. The pathogenesis of vulval melanoma remains largely unknown. Although ultraviolet radiation is an important pathogenic factor for cutaneous melanoma, it cannot be a factor in vulval melanoma. While possible mechanisms behind this association remain unclear, it is possible that chronic inflammation from genital LS leads to melanocytic distress and increased mutagenesis.
Keyphrases
  • skin cancer
  • oxidative stress
  • basal cell carcinoma