Early Expansion of Circulating Granulocytic Myeloid-derived Suppressor Cells Predicts Development of Nosocomial Infections in Patients with Sepsis.

Fabrice UhelImane AzzaouiMurielle GrégoireCéline PangaultJoelle DulongJean-Marc TadiéArnaud GacouinChristophe CamusLuc CynoberThierry FestYves Le TulzoMikael RousselKarin Tarte

Published in: American journal of respiratory and critical care medicine (2017)

M-MDSCs and G-MDSCs strongly contribute to T-cell dysfunction in patients with sepsis. More specifically, G-MDSCs producing arginase 1 are associated with a higher incidence of nosocomial infections and seem to be major actors of sepsis-induced immune suppression.

Keyphrases

septic shock
acute kidney injury
intensive care unit
induced apoptosis
acinetobacter baumannii
oxidative stress
cell cycle arrest
risk factors
high glucose
klebsiella pneumoniae
cell death
multidrug resistant
pi k akt