Pharmacological reduction of coagulation factor XI reduces macrophage accumulation and accelerates deep vein thrombosis resolution in a mouse model of venous thrombosis.
Kelley R JordanCory R WyattMeghan E FallonRandall L WoltjerEdward A NeuweltQuifang ChengDavid GailaniChristina U LorentzErik I TuckerOwen J T McCartyMonica T HindsKhanh P NguyenPublished in: Journal of thrombosis and haemostasis : JTH (2022)
Pharmacologic targeting of FXI enhances the early stages of experimental venous thrombus resolution in wild-type CD1 mice, and may be of interest for future clinical evaluation of the antibody in DVT and PTS.