Pharmacological reduction of coagulation factor XI reduces macrophage accumulation and accelerates deep vein thrombosis resolution in a mouse model of venous thrombosis.

Kelley R Jordan Cory R Wyatt Meghan E Fallon Randy Woltjer Edward A Neuwelt Quifang Cheng David Gailani Christina U Lorentz Erik I Tucker Owen J T McCarty Monica T Hinds Khanh P Nguyen

Published in: Journal of thrombosis and haemostasis : JTH (2022)

Pharmacologic targeting of FXI enhances the early stages of experimental venous thrombus resolution in wild-type CD1 mice, and may be of interest for future clinical evaluation of the antibody in DVT and PTS.

Keyphrases

wild type
mouse model
single molecule
adipose tissue
cancer therapy
nk cells