Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials.
Catherine M JankowskiPamela WolfeSarah J SchmiegeK Sreekumaran NairSundeep KhoslaMichael JensenDenise von MuhlenGail A LaughlinDonna Kritz-SilversteinJaclyn BergstromRichele BettencourtEdward P WeissDennis T VillarealWendy M KohrtPublished in: Clinical endocrinology (2018)
Dehydroepiandrosterone therapy may be an effective approach for preserving bone and muscle mass in women. Key questions are (a) the extent to which longer duration DHEA can attenuate the loss of bone and muscle in women, and (b) whether DHEA has a more favourable benefit-to-risk profile for women than oestrogen therapy.
Keyphrases
- bone mineral density
- body composition
- postmenopausal women
- polycystic ovary syndrome
- clinical trial
- resistance training
- pregnancy outcomes
- breast cancer risk
- cervical cancer screening
- skeletal muscle
- stem cells
- pregnant women
- bone loss
- mesenchymal stem cells
- study protocol
- smoking cessation
- phase iii
- replacement therapy