IGF1R signaling induces epithelial-mesenchymal plasticity via ITGAV in cutaneous carcinoma.

Marta Lopez-Cerda Laura Lorenzo-SanzVictoria da Silva-DizSandra LlopRosa M PeninJosep Oriol BermejoRichard de Goeij-de HaasSander R PiersmaThang V PhamConnie R JimenezJuan Martin-LiberalPurificación Muñoz

Published in: Journal of experimental & clinical cancer research : CR (2024)

Our results demonstrate that ITGAV is a prognostic biomarker of relapse in cSCCs that would allow improved patient stratification. ITGAV also collaborates with IGF1R to induce EMP in epithelial cancer cells and promotes cSCC progression, revealing a potential therapeutic strategy to block the generation of advanced mesenchymal cSCCs.

Keyphrases

bone marrow
stem cells
pi k akt
binding protein
growth hormone
case report
free survival
signaling pathway