Mitochondrial gene mutations in pediatric septic shock.
Junsung ParkEunju KangSeoon KangDeokhoon KimDahyun KimSeong Jong ParkWon Kyoung JhangPublished in: Pediatric research (2021)
This study is the first to examine mitochondrial DNA mutations in pediatric patients with septic shock using next-generation sequencing. A high frequency of mitochondrial DNA mutations was detected in these patients indicating an association with septic shock. This pilot study may provide a potential explanation for the association between mitochondrial dysfunction and septic shock on a genetic basis.