Thyroid dysfunction in Hashimoto's thyroiditis: a pilot study on the putative role of miR-29a and TGFβ1.
Maria Consiglia TrottaDaniela EspositoRaffaela CarotenutoRosa di FraiaLucia Digitale SelvaggioFrancesca AllossoMarina RussoGiacomo AccardoRoberto AlfanoMichele D'AmicoDaniela PasqualiPublished in: Endocrine (2024)
In conclusion, Hypo-HT patients had lower levels of serum miR-29a and higher levels of TGFβ1 in comparison with Eu-HT patients. Worthy of note, subst-HT patients showed restored serum miR-29a levels compared with Hypo-HT group, associated with lower serum TGFβ1. These novel findings may suggest a possible impact of replacement therapy with levothyroxine on serum miR-29a levels in HT.