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Prevalence and predictors for cisplatin-induced toxicities in Zimbabwean women with cervical cancer.

Oppah KuguyoAlice MatimbaMugove G MadziyireThulani MagwaliCollet DandaraCharles Fb NhachiNomsa Tsikai
Published in: Future oncology (London, England) (2024)
Aim: To describe treatment-induced toxicities (TITs) and associated factors in Zimbabwean cancer patients receiving cisplatin. Methods: In total, 252 Zimbabwean women with cervical cancer, receiving cisplatin were followed up over 12 months for TITs and disease status. Results: Peripheral neuropathy (70%) and ototoxicity (53%) were most prevalent. Advanced disease (OR = 1.3; 95% CI = 1.1-1.5; p = 0.02), pain comedications (OR = 1.3; 95% CI = 1.1-1.5; p = 0.03), alcohol (OR = 2.8; 95% CI = 1.1-7.5; p = 0.04) and comorbidities (OR = 1.2; 95% CI = 1.1-1.4; p = 0.04) increased peripheral neuropathy and ototoxicity risk. Older age increased risk of disease progression (OR = 1.9; 95% CI = 1.4-3.0; p = 0.033). Conclusion: High peripheral neuropathy and ototoxicity prevalence were observed, which are not routinely monitored in Zimbabwe. There is a need for capacity building to incorporate comprehensive TIT testing and optimize cancer care in Zimbabwe.
Keyphrases
  • risk factors
  • chronic pain
  • papillary thyroid
  • physical activity
  • high glucose
  • young adults
  • alcohol consumption
  • smoking cessation
  • lymph node metastasis