Celecoxib Exerts a Therapeutic Effect Against Demyelination by Improving the Immune and Inflammatory Microenvironments.

Peipei CaoHao ZhangHuiling MengYajia ChengHaiqi XuSiwen ZangZongjin LiJianlin CuiYu-Hao Li

Published in: Journal of inflammation research (2020)

Inhibition of COX-2 contributed to the transformation of microglia/macrophages from the M1 to the M2 phenotype, improved the inflammatory microenvironment, and suppressed caspase-dependent apoptosis, thus exerting a therapeutic effect against demyelination.

Keyphrases

oxidative stress
cell death
endoplasmic reticulum stress
induced apoptosis
stem cells
inflammatory response
neuropathic pain
spinal cord injury