Cerium-Encapsulated Sb III -Se IV -Templating Polyoxotungstate for Electrochemically Sensing Human Multidrug Resistance Gene Segment.

A tower-like Sb III -Se IV -templating polyoxotungstate [H 2 N(CH 3 ) 2 ] 12 Na 7 H 3 [Ce 0.5 /Na 0.5 (H 2 O) 5 ] 2 [SbSe 2 W 21 O 75 ] 2 ·50H 2 O ( 1 ) was synthesized, whose skeleton is assembled from two prolonged lacunary Dawson [SbSe 2 W 21 O 75 ] 13- units and two [Ce 0.5 /Na 0.5 (H 2 O) 5 ] 2+ linkers. The uncommon [SbSe 2 W 21 O 75 ] 13- unit can be viewed as a combination of one [SeW 6 O 21 ] 2- group grafted onto a trivacant Dawson [SbSeW 15 O 54 ] 11- subunit. The conductive composite 1 -Au@rGO containing 1 , gold nanoparticles, and reduced graphene oxide (rGO) was conveniently prepared, using which the 1 -Au@rGO-based electrochemical genosensor was constructed for detecting human multidrug resistance gene segment. This work enriches structural types of dual-heteroatom-inserted polyoxometalates and promotes the application of polyoxometalates in genosensors.