AuNPs Decorated PLA Stereocomplex Micelles for Synergetic Photothermal and Chemotherapy.
Xiaoshan FanZheng LuoEnyi YeMingliang YouMinting LiuYe YunXian Jun LohYun-Long WuZibiao LiPublished in: Macromolecular bioscience (2021)
A unique platform for combined photothermal and chemotherapy using PLA stereocomplex (PLA SC) micelles-induced hybrid gold nanocarriers is designed. The PLA SC micelles, made from the self-assembly of poly(ethylene glycol)-block-poly(l-lactide) (PEG-PLLA) and poly(2-(dimethylamino) ethyl methacrylate)-block-poly(d-lactide) (PDMAEMA-PDLA), for the first time are used as a template to fabricate the hybrid PLA SC@Au core-shell nanocarriers, in which the anticancer drugs are encapsulated within the core, while the Au nanoparticles are tethered in the shell via the in situ reduction of AuCl4 - by PDMAEMA. The obtained PLA SC@Au hybrid nanocarriers exhibit low toxicity and remarkable photothermal effect. Upon near-infrared laser irradiation, the on-site photothermal therapy can further induce an accelerated drug release from the hybrid nanocarrier reservoir via hyperthermia heating of the nanocarriers, thus leading to a synergistic photothermal and chemotherapy toward a significantly improved efficacy in tumor shrinkage. The as-designed PLA SC@Au hybrid nanocarriers, with their biocompatible compositions, dual-drug delivery characteristics, and combined photothermal/chemotherapy, show high potential as a novel platform for cancer treatment.
Keyphrases
- drug delivery
- cancer therapy
- drug release
- sensitive detection
- reduced graphene oxide
- locally advanced
- high throughput
- squamous cell carcinoma
- drug induced
- photodynamic therapy
- emergency department
- oxidative stress
- ionic liquid
- visible light
- risk assessment
- chemotherapy induced
- high resolution
- high glucose
- quantum dots
- hyaluronic acid
- human health
- stress induced
- endothelial cells