Drug-exposed cancer-associated fibroblasts facilitate gastric cancer cell progression following chemotherapy.
Takahiro IshiiAyako SuzukiTakeshi KuwataShoshi HisamitsuHiroko HashimotoYuuki OharaKazuyoshi YanagiharaShuichi MitsunagaTakayuki YoshinoTakahiro KinoshitaAtsushi OchiaiKohei ShitaraGenichiro IshiiPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2021)
Our findings provide evidence regarding the interactions between GC cells and CAFs in the tumor microenvironment following chemotherapy, suggesting that ligands for gp130 may be novel therapeutic targets for suppressing or preventing metastasis in GC.
Keyphrases
- induced apoptosis
- locally advanced
- cell cycle arrest
- signaling pathway
- single cell
- gas chromatography
- cell therapy
- squamous cell carcinoma
- chemotherapy induced
- emergency department
- endoplasmic reticulum stress
- stem cells
- mass spectrometry
- radiation therapy
- cell proliferation
- pi k akt
- high resolution
- mesenchymal stem cells
- tandem mass spectrometry