Heat Transfer and Residence Time Distribution in Plug Flow Continuous Oscillatory Baffled Crystallizers.

Heat transfer coefficients in a continuous oscillatory baffled crystallizer (COBC) with a nominal internal diameter of 15 mm have been determined as a function of flow and oscillatory conditions typically used under processing conditions. Residence time distribution measurements show a near-plug flow with high Peclet numbers on the order of 100-1000 s, although there was significant oscillation damping in longer COBC setups. Very rapid heat transfer was found under typical conditions, with overall heat transfer coefficients on the order of 100 s W m-2 K-1. Furthermore, poor mixing in the COBC cooling jacket was observed when lower jacket flow rates were implemented in an attempt to decrease the rate of heat transfer in order to achieve more gradual temperature profile along the crystallizer length. Utilizing the experimentally determined overall heat transfer coefficients, a theoretical case study is presented to investigate the effects of the heat transfer rate on temperature and supersaturation profiles and to highlight potential fouling issues during a continuous plug flow cooling crystallization.