PLEKHA5 regulates tumor growth in metastatic melanoma.

Hongyi ZhangHuifang ZhuGang DengChristopher R ZitoVictor O OriaChetan K RaneShenqi ZhangSarah A WeissThuy T TranAdebowale AdeniranFanfan ZhangJiangbing ZhouYuval KlugerMarcus W BosenbergHarriet M KlugerLucia B Jilaveanu

Published in: Cancer (2019)

This study further supports the role of PLEKHA5 as a regulator of melanoma growth at distant sites, including the brain. Furthermore, the results highlight the significance of PDCD4 dysregulation in disseminated melanoma and implicate PDCD4 as a possible causal link between PLEKHA5 and cell proliferation and growth.

Keyphrases

cell proliferation
lymph node
skin cancer
white matter
resting state
cell cycle
transcription factor
functional connectivity
signaling pathway
cerebral ischemia