Protein disulfide isomerase-A1 regulates intraplatelet reactive oxygen species-thromboxane A2 -dependent pathway in human platelets.

Kamil Przyborowski Anna Kurpinska Dagmara W Wojkowska Patrycja Kaczara Joanna Suraj-Prażmowska Kamil Karolczak Agata Malinowska Agnieszka Pelesz Agnieszka Kij Ivars Kalvins Cezary Watala Stefan Chlopicki

Published in: Journal of thrombosis and haemostasis : JTH (2021)

PDIA1 acts as an intraplatelet regulator of the ROS-TxA2 pathway in collagen-GP VI receptor-mediated platelet activation that is a mechanistically distinct pathway from extracellular regulation of αIIbβ3 integrin by PDIA3.

Keyphrases

reactive oxygen species
endothelial cells
dna damage
transcription factor
oxidative stress
induced pluripotent stem cells
small molecule