Circulating Endocannabinoids and N-Acylethanolamines in Individuals with Cannabis Use Disorder-Preliminary Findings.
Nadia BoachieErin GaudetteRichard P BazinetLin LinRachel Fynvola TyndaleEsmaeil MansouriMarilyn Ann HuestisJunchao TongBernard Le FollStephen J KishTony P GeorgeIsabelle BoileauPublished in: Brain sciences (2023)
Our preliminary findings, requiring replication, might suggest that activity of the endocannabinoid system is elevated in chronic cannabis users. It is unclear whether this elevation is a compensatory response or a predating state. Studies examining endocannabinoids and NAEs during prolonged abstinence as well as the potential role of DHEA in craving are warranted.