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miR-663a inhibits tumor growth and invasion by regulating TGF-β1 in hepatocellular carcinoma.

Chengshuo ZhangBaomin ChenAo JiaoFeng LiNing SunGuoqing ZhangJialin Zhang
Published in: BMC cancer (2018)
miR-663a acts as a tumor suppressor and exerts a substantial role in inhibiting the proliferation, invasion, and tumorigenesis of HCC by regulating TGF-β1 in vitro and in vivo. These observations indicate that miR-663a may be a suitable diagnostic, therapeutic, and prognostic target for the treatment of HCC.
Keyphrases
  • cell proliferation
  • long non coding rna
  • long noncoding rna
  • signaling pathway
  • transforming growth factor
  • cell migration
  • epithelial mesenchymal transition
  • combination therapy