Overexpression of the transcription factors OCT4 and KLF4 improves motor function after spinal cord injury.

Xianpeng HuangChenggui WangXiaopeng ZhouJingkai WangKaishun XiaBiao YangZhe GongLiwei YingChao YuKesi ShiJiawei ShuFeng ChengBin HanChengzhen LiangFangcai LiQixin Chen

Published in: CNS neuroscience & therapeutics (2020)

In summary, these results suggest that overexpression of the transcription factors OCT4 and KLF4 could induce astrocyte reprogramming, which subsequently improves remyelination and functional recovery after SCI.

Keyphrases

transcription factor
optical coherence tomography
dna binding
diabetic retinopathy
spinal cord injury
genome wide identification
cell proliferation