Anti-CD99 Antibody Therapy Triggers Macrophage-Dependent Ewing Cell Death In Vitro and Myeloid Cell Recruitment In Vivo.
Allison F O'NeillEvelyn M NguyenEvelyn D MaldonadoMatthew R ChangJiusong SunQuan ZhuWayne A MarascoPublished in: Antibodies (Basel, Switzerland) (2024)
These studies are the first to demonstrate the role of human immune effector cells in anti-CD99-mediated Ewing tumor death. We propose that the engagement of CD99 by NOA2 results in the recruitment of intratumoral macrophages. In addition, interruption of the CD99:PILRα checkpoint axis may be a relevant therapeutic approach to activate tumor-associated macrophages.