Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse.

Kang-Moon SongWoo-Jean KimMin-Ji ChoiAnita LimanjayaKalyan GhatakNguyen Nhat MinhJiyeon OckGuo Nan YinSoon-Sun HongJun-Kyu SuhJi Kan Ryu

Published in: Andrology (2020)

DKK3 restored cavernous vascular integrity and improved erectile function in diabetic mice. Therapeutic cavernous angiogenesis by the use of DKK3 will be a promising therapeutic strategy to treat diabetic erectile dysfunction.

Keyphrases

wound healing
endothelial cells
type diabetes
vascular endothelial growth factor
benign prostatic hyperplasia
mouse model
genome wide
copy number
gene expression
dna methylation