Reliability and construct validity of the ACTIVLIM-Hemo and Haemophilia Activities List (HAL) questionnaires in individuals with haemophilia.

Sébastien Lobet Cedric Hermans Valérie-Anne Chantrain Anthe Foubert Catherine Marie Lambert Massimo Penta

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2024)

ACTIVLIM-Hemo stands as a reliable and valid instrument for assessing activity limitations in PwH. Both instruments exhibited significant correlations with demographic and clinical factors, but ACTIVLIM-Hemo displayed a more homogeneous construct. Given its linear scale and lower MDC95 and better targeting, ACTIVLIM-Hemo shows promise as a patient-centric instrument for assessing responsiveness to treatment during individual follow-up.

Keyphrases

patient reported outcomes
case report
drug delivery
psychometric properties
replacement therapy