Oxidative stress causes muscle structural alterations via p38 MAPK signaling in COPD mouse model.

Yosuke ManoManabu TsukamotoKe-Yong WangTakayuki NabeshimaKenji KosugiTakafumi TajimaYoshiaki YamanakaHitoshi SuzukiMakoto KawasakiEiichiro NakamuraQian ZhouKagaku AzumaTamiji NakashimaYuki TamuraKarina KozakiKoichi NakazatoYun-Shan LiKazuaki KawaiKazuhiro YateraAkinori Sakai

Published in: Journal of bone and mineral metabolism (2022)

This study provides first evidence in COPD mouse model that oxidative stress trigger a series of muscle structural changes. Our findings suggest a novel target for sarcopenia in COPD.

Keyphrases

mouse model
oxidative stress
chronic obstructive pulmonary disease
lung function
skeletal muscle
ischemia reperfusion injury
induced apoptosis
cystic fibrosis
air pollution
endoplasmic reticulum stress