Ependymomas in infancy: underlying genetic alterations, histological features, and clinical outcome.

Stephanie T JüngerFelipe AndreiuoloMartin MynarekEvelyn DörnerAnja Zur MühlenStefan RutkowskiAndre O von BuerenTorsten Pietsch

Published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2020)

Infant ependymomas seem to fall into three biological entities, with supratentorial tumors carrying RELA or YAP fusions and PFA posterior fossa ependymomas. The latter showed a poor outcome even though chromosome 1q gain was absent.

Keyphrases

copy number
genome wide
weight gain
gene expression
dna methylation
body mass index