Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation.

Tore K DanielsenRavinea ManotheepanMani SadrediniIda S LerenAndrew G EdwardsKevin P VincentStephan E LehnartOle M SejerstedIvar SjaastadKristina H HaugaaMathis K Stokke

Published in: PloS one (2018)

In CPVT1, VT propensity depends on individual heart rate thresholds for PVCs. Through converging data from clinical exercise stress-testing, cellular studies and computational modelling, we confirm the heart rate-independent pro-arrhythmic effects of βAR stimulation in CPVT1, but also identify an independent and synergistic contribution from effects of high heart rate.

Keyphrases

heart rate
heart rate variability
blood pressure
high intensity
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