Germline Mutations of Holliday Junction Resolvase Genes in Multiple Primary Malignancies Involving Lung Cancer Lead to PARP Inhibitor Sensitization.
Haoran WangYuping ChenXinshu WangBinhao HuangJuntao XieHui YinJie YangJinhuan WuJian YuanJie ZhangPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
This is the first study to map the profile of germline mutations in patients with MPM involving lung cancer. This study may shed light on early prevention and novel targeted therapies for MPM involving patients with lung cancer with HJR mutations.