Adipose Tissue-Derived Mesenchymal Stem Cells Alter Metabolites of Brain Cholesterol Homeostasis in An Alzheimer's Model.
Mehrnaz Karimi DarabiZahra NazeriArash RafeeiniaSeyedeh Pardis PezeshkiAlireza KheirollahYaghoob FarboodMaryam AdelipourShirin AzizidoostMaryam CheraghzadehPublished in: Cell journal (2023)
The findings indicate that MSC therapy has the potential to improve AD by modulating brain cholesterol homeostasis and promoting the differentiation of stem cells into nerve cells. The results emphasize the importance of investigating the role of cholesterol metabolites in the context of MSC therapy to gain deeper insights into underlying mechanisms of the therapeutic efficacy of MSCs in AD.
Keyphrases
- stem cells
- low density lipoprotein
- adipose tissue
- ms ms
- resting state
- induced apoptosis
- white matter
- mesenchymal stem cells
- functional connectivity
- signaling pathway
- insulin resistance
- cell cycle arrest
- cerebral ischemia
- cell therapy
- cognitive decline
- metabolic syndrome
- cell death
- multiple sclerosis
- risk assessment
- skeletal muscle
- high fat diet
- bone marrow
- blood brain barrier
- endoplasmic reticulum stress
- replacement therapy
- smoking cessation