Differences in 5'untranslated regions highlight the importance of translational regulation of dosage sensitive genes.

Nechama WiederElston N D'SouzaAlexandra C Martin-GearyFrederik H LassenJonathan Talbot-MartinMaria FernandesSonia P ChothaniOwen J L RackhamSebastian SchaferJulie L AspdenDaniel G MacArthurRobert W DaviesNicola Whiffin

Published in: Genome biology (2024)

Our results confirm the importance of post-transcriptional regulation through 5'UTRs in tight regulation of mRNA and protein levels, particularly for genes where changes in dosage are deleterious and lead to disease. Finally, to support gene-based investigation we release a web-based browser tool, VuTR, that supports exploration of the composition of individual 5'UTRs and the impact of genetic variation within them.

Keyphrases

genome wide
genome wide identification
genome wide analysis
bioinformatics analysis
binding protein
blood brain barrier
dna methylation
copy number
transcription factor
protein protein
small molecule
amino acid