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Addendum to: The relationship between sperm nuclear DNA fragmentation, mitochondrial DNA fragmentation and copy number in normal and abnormal human ejaculates.

Ana TímermansFátima OteroManuel GarridoJaime GosálvezStephen D JohnstonJosé Luis Fernández García
Published in: Andrology (2023)
mtDNA fragmentation and loss occur post ejaculation. Their dynamics are likely to be associated with different and/or uncoupled mechanisms to that which cause nuclear DNA fragmentation. Our results indicate that while mtDNA fragmentation is not influenced by the sperm quality, the number of copies of sperm mtDNAcn can potentially serve as a risk factor for predicting non-normozoospermia.
Keyphrases
  • mitochondrial dna
  • copy number
  • genome wide
  • dna methylation
  • circulating tumor
  • single molecule
  • cell free