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Enantioselective Nickel-Catalyzed Reductive anti -Arylative Annulation of Alkyne-Tethered Malononitriles to Construct Quaternary Stereocenters.

Wei-Min LiuZhiwu LuQiang WeiWen-Bo Liu
Published in: Organic letters (2023)
A nickel-catalyzed reductive desymmetrizing annulation of alkyne-tethered malononitriles and (hetero)aryl iodides is reported for the access of cyclohexenones containing an α-all-carbon quaternary stereocenter. The use of a nickel catalyst derived from an electron-rich phosphinooxazoline ligand combined with iron powder as a reductant is crucial to the success of this transformation.
Keyphrases
  • reduced graphene oxide
  • room temperature
  • metal organic framework
  • oxide nanoparticles
  • carbon nanotubes
  • gold nanoparticles
  • ionic liquid
  • iron deficiency
  • solar cells
  • electron transfer