Cobalt-Catalyzed Csp3-Csp3 Cross-Coupling of Functionalized Alkylzinc Reagents with Alkyl Iodides.
Ferdinand H LutterLucie GrokenbergerMaximilian BenzPaul KnochelPublished in: Organic letters (2020)
A mild cobalt-catalyzed Negishi-type cross-coupling of various functionalized dialkylzinc reagents with primary and secondary alkyl iodides in acetonitrile is reported using a combination of 20% CoCl2 and chelating nitrogen ligands. The method allows the construction of molecules with alkyl chains bearing sensitive functional groups at room temperature.